Yes. Several categories of biological-age testing exist, each with different tradeoffs and interpretive utility.
1. Epigenetic clocks (DNA methylation). The most established biological-age technology. Uses methylation patterns at specific CpG sites in DNA to estimate biological age. Horvath's 2013 Genome Biology paper established the foundational multi-tissue clock (Horvath, 2013). Levine's PhenoAge (2018) and Belsky's DunedinPACE (2022) are more recent refinements optimized for different use cases (Levine, 2018; Belsky, 2022).
Consumer versions exist (TruDiagnostic, Elysium Health's Index, and others). Cost typically $250-500. Best used for baseline + retest 12-24 months later to see if interventions moved the needle.
2. Biomarker composite scores. Combine multiple standard blood biomarkers into a composite biological-age estimate. Klemera-Doubal method is the underlying statistical framework. Levine's PhenoAge biomarker composite uses 9 markers including hs-CRP, albumin, creatinine, glucose, HbA1c (Levine, 2018). Less expensive than epigenetic clocks, less established but improving.
3. Telomere length testing. Older biological-age approach. Consumer versions exist but reliability has been questioned in the literature. Less widely recommended by aging researchers currently.
4. Skin-specific biological age. An emerging category. Uses skin autofluorescence (for AGEs), imaging analysis, or specific dermatological markers. Not yet widely available at consumer scale.
What the JenSkin panel is: Not a biological-age composite. Instead, it measures nine specific, actionable biomarkers of skin-aging biology — with a report that translates what each means for your skin specifically. Different tool, different question.
Reasonable stack for a person interested in aging generally: epigenetic clock once, JenSkin panel for the skin-specific picture, retest what matters over time.